Morpholine → HCID 11247604, compound

HRID 644527Notes

Reaction equation

HRID 644527 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[C:14]3[N:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:16]=[N:17][C:13]=3[CH:12]=[C:11]([C:24]([F:27])([F:26])[F:25])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>CN1C(=O)CCC1>[N:28]1([CH2:2][C:3]2[CH:4]=[C:5]([C:9]3[C:14]4[N:15]([C:18]5[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=5)[CH:16]=[N:17][C:13]=4[CH:12]=[C:11]([C:24]([F:27])([F:26])[F:25])[CH:10]=3)[CH:6]=[CH:7][CH:8]=2)[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 67485520HCID 67485520, compound

Product 1

HCID 11247604HCID 11247604, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

This was prepared analogeously to the above product from 7-(3-(chloromethyl)phenyl)-1-phenyl-5-trifluoromethylbenzimidazole (0.97 g, 2.5 mmol) and morpholine (0.74 ml, 7.5 mmol) in NMP (5 ml) to yield 0.81 g (74%), m/z, 382.1 (M+H)+.

Workup

  1. customto yield 0.81 g (74%), m/z, 382.1 (M+H)+

Sources & evidence

ORD record
ord-0af56ed888b8494ba83c897d0cab2cce
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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