Dimethylamine → HCID 11773818, compound

HRID 644528Notes

Reaction equation

HRID 644528 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[C:14]3[N:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:16]=[N:17][C:13]=3[CH:12]=[C:11]([C:24]([F:27])([F:26])[F:25])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:28][NH:29][CH3:30]>CN1C(=O)CCC1>[CH3:28][N:29]([CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[C:14]3[N:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:16]=[N:17][C:13]=3[CH:12]=[C:11]([C:24]([F:27])([F:26])[F:25])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1)[CH3:30]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 67485520HCID 67485520, compound

Product 1

HCID 11773818HCID 11773818, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

This was prepared analogeously to the above product from 7-(3-(chloromethyl)phenyl)-1-phenyl-5-trifluoromethylbenzimidazole (0.97 g, 2.5 mmol) and dimethyl amine (2 ml) in NMP (5 ml) to yield 0.54 g (55%), m/z, 396.2 (M+H)+.

Workup

  1. customto yield 0.54 g (55%), m/z, 396.2 (M+H)+

Sources & evidence

ORD record
ord-cb80e984d15c487aba4d8c5e074fc460
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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