反应详情

To an ice-cooled solution of 7-(3-acetylphenyl)-1-phenyl-5-trifluoromethylbenzimidazole ((0.76 g, 2.0 mmol) in anhydrous tetrahydrofurane (5 ml) was added a solution of methylmagnesium bromide (1.0 ml, 3M) dropwise over 5 min. The ice-bath was removed and the mixture was stirred at ambient temperature for 4 hours. Aqueous ammonium chloride, and subsequently ethyl acetate, was added.

1. customThe ice-bath was removed
2. additionAqueous ammonium chloride, and subsequently ethyl acetate, was added