Piperidine → HCID 11280537, compound

HRID 644554Notes

Reaction equation

HRID 644554 reaction equation
[N:1]1([CH2:7][C:8]#[C:9][C:10]2[C:15]3[N:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:17]=[N:18][C:14]=3[CH:13]=[C:12]([C:25]([F:28])([F:27])[F:26])[CH:11]=2)[CH2:6][CH2:5]O[CH2:3][CH2:2]1.N1CCCC[CH2:30]1>>[C:19]1([N:16]2[C:15]3[C:10]([C:9]#[C:8][CH2:7][N:1]4[CH2:6][CH2:5][CH2:30][CH2:3][CH2:2]4)=[CH:11][C:12]([C:25]([F:28])([F:27])[F:26])=[CH:13][C:14]=3[N:18]=[CH:17]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 11246118HCID 11246118, compound

Product 1

HCID 11280537HCID 11280537, compoundYield 17%

Procedure

This was prepared in a similar manner to 7-(3-(4-morpholinyl)prop-1-ynyl)-1-phenyl-5-trifluoromethylbenzimidazole using piperidine in place of morpholine to realise the desired product (13 mg, 17%) m/z, 384.4 (M+H)+.

Sources & evidence

ORD record
ord-061b211c7469476aaae218018f487c6e
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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