反应详情

温度

80 °C

To a solution of 280 mg of methyl 3-[(2S)-2-{[(1S)-1-phenylethyl]amino}propyl]benzoate in 6.8 ml of ethanol were added 30 mg of 20% palladium-carbon hydroxide (wet) and 320 mg of ammonium formate, followed by stirring at 80° C. for 4 hours. The reaction mixture was filtered over Celite and the solvent was then evaporated under reduced pressure. To the obtained residue were added a saturated aqueous sodium hydrogen carbonate solution and chloroform to carry out a layer separation operation, followed by drying over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain 180 mg of methyl 3-[(2S)-2-aminopropyl]benzoate.

1. filtrationThe reaction mixture was filtered over Celite
2. customthe solvent was then evaporated under reduced pressure
3. additionTo the obtained residue were added a saturated aqueous sodium hydrogen carbonate solution and chloroform
4. customa layer separation operation
5. dry with materialby drying over anhydrous magnesium sulfate
6. customThe solvent was evaporated under reduced pressure