HCID 68717789, compound → HCID 68716121, compound

HRID 644562Notes

Reaction equation

HRID 644562 reaction equation
C([O:3][C:4](=[O:26])[C@H:5]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[NH:6][C:7](=[O:18])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:17])[CH:15]=[CH2:16])C>CO>[C:14]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][C:7]([NH:6][C@H:5]([C:4]([OH:26])=[O:3])[CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:18])(=[O:17])[CH:15]=[CH2:16]

Participants

3

Reactant 1

HCID 68717789HCID 68717789, compound

Product 1

HCID 68716121HCID 68716121, compoundYield 97.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.72 g of the N-(6-acryloylaminocaproyl)phenylalanine ethyl ester obtained in Reference Example 13 was added to 50 ml of methanol containing 1 N sodium hydroxide, followed by stirring at room temperature for 4 hours. After the reaction, an H+ cation exchange resin, Dowex 50W (Dow Chemical Co.), was added for neutralization. The ion exchange resin was then filtered off, and the filtrate was evaporated to afford the target compound (0.65 g).

Workup

  1. customAfter the reaction
  2. filtrationThe ion exchange resin was then filtered off
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-09760d08f37941ab8f8b8b735619ba55
Source dataset
uspto-grants-2010_04
Patent number
US07700701B2

Reaction notes

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