Hydrogen chloride-ethyl acetate → HCID 86713499, compound

HRID 64472Notes

Reaction equation

HRID 64472 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[C:10]3[N:11]([C:15]([C:19]([NH:21][C@H:22]4[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23]4)=[O:20])=[C:16]([CH3:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:28].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:28].[CH:1]1([CH2:7][O:8][C:9]2[C:10]3[N:11]([C:15]([C:19]([NH:21][C@H:22]4[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23]4)=[O:20])=[C:16]([CH3:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 71478936HCID 71478936, compound

Product 1

HCID 86713499HCID 86713499, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 245 mg of 8-(cyclohexylmethoxy)-2-methyl-N-[(3S)-1-methylpyrrolidin-3-yl]imidazo[1,2-a]pyridine-3-carboxamide were added 12 ml of ethyl acetate and 364 μl of a 4 M hydrogen chloride/ethyl acetate solution, followed by stirring. The resulting solid was collected by filtration and dried to obtain 258 mg of 8-(cyclohexylmethoxy)-2-methyl-N-[(3S)-1-methylpyrrolidin-3-yl]imidazo[1,2-a]pyridine-3-carboxamide hydrochloride.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-89b1dd9ce82a47e0852adcc0a1899a8a
Source dataset
uspto-grants-2016_09
Patent number
US09447090B2

Reaction notes

Loading…