tert-Butyl methylcarbamate → 1,1-Dimethylethyl (4-formyl-3-methylphenyl)methylcarbamate

HRID 644743Notes

Reaction equation

HRID 644743 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([CH3:10])[CH:3]=1.[CH3:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16]>>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:3][C:4]=1[CH3:10])=[O:7]

Participants

3

Reactant 2

HCID 527635tert-Butyl methylcarbamateHCID 135551504-Bromo-2-methylbenzaldehyde

Product 1

HCID 866181121,1-Dimethylethyl (4-formyl-3-methylphenyl)methylcarbamate

Procedure

The title compound was prepared from crude 4-bromo-2-methylbenzaldehyde (D91) and 1,1-dimethylethyl methylcarbamate (D83) using a method similar to that described for D84 in Description 84. δH (CDCl3, 400 MHz) 10.20 (1H, s), 7.76 (1H, d), 7.28 (1H, dd), 7.19 (1H, d), 3.31 (3H, s), 2.66 (3H, s), 1.49 (9H, s).

Sources & evidence

ORD record
ord-a40fb7f683f64bb291d5ebb794f090bb
Source dataset
uspto-grants-2010_04
Patent number
US07700599B2

Reaction notes

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