Fexofenadine → Fexofenadine Hydrochloride

Participants

Reaction Steps

To a mixture of ethyl acetate and isopropanol (900:100 ml), is added Fexofenadine Form A (100 g; prepared as per above procedure), followed by slow addition of isopropanol hydrogen chloride (prepared by purging hydrogen chloride to isopropyl alcohol) to pH 2. The reaction mass is then filtered and to the filtrate is added several crystals of Form X of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzene acetic acid hydrochloride. The reaction mixture is then stirred for 2-4 hours. The solid obtained is filtered, washed with cyclohexane (200 ml) and dried below 100° C. to constant weight to obtain the desired Form X of Fexofenadine Hydrochloride

Provenance & Evidence