反应详情

To a mixture of ethyl acetate and isopropanol (900:100 ml), is added Fexofenadine Form A (100 g; prepared as per above procedure), followed by slow addition of isopropanol hydrogen chloride (prepared by purging hydrogen chloride to isopropyl alcohol) to pH 2. The reaction mass is then filtered and to the filtrate is added several crystals of Form X of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzene acetic acid hydrochloride. The reaction mixture is then stirred for 2-4 hours. The solid obtained is filtered, washed with cyclohexane (200 ml) and dried below 100° C. to constant weight to obtain the desired Form X of Fexofenadine Hydrochloride

1. customForm A (100 g; prepared as per above procedure)
2. filtrationThe reaction mass is then filtered and to the filtrate
3. additionis added several crystals of Form X of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzene acetic acid hydrochloride
4. customThe solid obtained
5. filtrationis filtered
6. washwashed with cyclohexane (200 ml)
7. customdried below 100° C. to constant weight