6,8-dimethyl-4-oxo-4H-[1,7]naphthyridine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester → HCID 58662434, 화합물

HRID 644813노트

반응식

HRID 644813 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[C:10]([CH3:18])[N:11]=[C:12]([CH3:17])[CH:13]=2)[N:8]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH:7]=1)=[O:5])C.[CH2:29]([Mg]Br)[CH3:30]>C1COCC1.[Cu](I)I>[CH3:1][O:3][C:4]([CH:6]1[C:15](=[O:16])[C:14]2[C:9](=[C:10]([CH3:18])[N:11]=[C:12]([CH3:17])[CH:13]=2)[N:8]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH:7]1[CH2:29][CH3:30])=[O:5]

참가 물질

5

반응물 2

HCID 586624486,8-dimethyl-4-oxo-4H-[1,7]naphthyridine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl esterHCID 178418443HCID 178418443, 화합물

생성물 1

HCID 58662434HCID 58662434, 화합물

시약·촉매·용매 2

HCID 83717Copper iodide촉매HCID 8028Tetrahydrofuran용매

실험 절차

This compound can be obtained by reacting a stirred suspension of 6,8-dimethyl-4-oxo-4H-[1,7]naphthyridine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester, prepared in step (iii) and CuI (copper iodide) in THF, with freshly prepared EtMgBr (ethyl magnesium bromide) at −78° C., followed by a typical workup.

후처리

  1. customThis compound can be obtained

출처 및 근거

ORD 기록
ord-372cfc7d633b46938fe3c2f4841a3745
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700774B2

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