Sodium Hydroxide → HCID 58662444, compound

HRID 644814Notes

Reaction equation

HRID 644814 reaction equation
COC([CH:5]1[C:14](=[O:15])[C:13]2[C:8](=[C:9]([CH3:17])[N:10]=[C:11]([CH3:16])[CH:12]=2)[N:7]([C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:19])[CH:6]1[CH2:28][CH3:29])=O.[OH-].[Na+]>C(O)C>[CH2:21]([O:20][C:18]([N:7]1[C:8]2[C:13](=[CH:12][C:11]([CH3:16])=[N:10][C:9]=2[CH3:17])[C:14](=[O:15])[CH2:5][CH:6]1[CH2:28][CH3:29])=[O:19])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 586624342-ethyl-6,8-dimethyl-4-oxo-3,4-dihydro-2H-[1,7]naphthyridine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

Product 1

HCID 58662444HCID 58662444, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound can be obtained by reacting a solution of 2-ethyl-6,8-dimethyl-4-oxo-3,4-dihydro-2H-[1,7]naphthyridine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester, in ethanol, with 2N NaOH at reflux temperature, for a time period from about 0.5 h to about 2 h, followed by a typical workup.

Workup

  1. customThis compound can be obtained
  2. waitfor a time period from about 0.5 h to about 2 h

Sources & evidence

ORD record
ord-143515e048894d4cafb4a322cc8274a5
Source dataset
uspto-grants-2010_04
Patent number
US07700774B2

Reaction notes

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