Pyridine → HCID 136385125, compound

HRID 644817Notes

Reaction equation

HRID 644817 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:17])=[N:13][C:14]=2[CH3:16])[C:9](=O)[CH2:8][CH:7]1[CH2:19][CH3:20])=[O:5])[CH3:2].[NH2:21][OH:22].Cl.N1C=CC=CC=1>>[CH2:1]([O:3][C:4]([N:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:17])=[N:13][C:14]=2[CH3:16])[C:9](=[N:21][OH:22])[CH2:8][CH:7]1[CH2:19][CH3:20])=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 58662430HCID 58662430, compound

Product 1

HCID 136385125HCID 136385125, compound

Procedure

This compound can be prepared by reacting an ethanolic solution of 2-ethyl-6,8-dimethyl-4-oxo-3,4-dihydro-2H-[1,7]naphthyridine-1-carboxylic acid ethyl ester, with NH2OH.HCl (2-3 eqv) and pyridine (1-3 eqv), typically at reflux temperature for about 2 to about 6 h, followed by a typical workup procedure.

Workup

  1. customThis compound can be prepared

Sources & evidence

ORD record
ord-f052ab0ef45f4e0e9e4bccaa999c85c9
Source dataset
uspto-grants-2010_04
Patent number
US07700774B2

Reaction notes

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