HCID 136385125, compound → HCID 58662425, compound

HRID 644818Notes

Reaction equation

HRID 644818 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:17])=[N:13][C:14]=2[CH3:16])[C:9](=[N:18]O)[CH2:8][CH:7]1[CH2:20][CH3:21])=[O:5])[CH3:2]>C(O)(=O)C.[Zn]>[CH2:1]([O:3][C:4]([N:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:17])=[N:13][C:14]=2[CH3:16])[CH:9]([NH2:18])[CH2:8][CH:7]1[CH2:20][CH3:21])=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 136385125HCID 136385125, compound

Product 1

HCID 58662425HCID 58662425, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

This compound can be prepared by reacting a solution of 2-ethyl-4-hydroxyimino-6,8-dimethyl-3,4-dihydro-2H-[1,7]naphthyridine-1-carboxylic acid ethyl ester in acetic acid with Zn (5 to 10 eqv), typically at reflux temperature, for about 1 h to about 5 h, followed by a typical workup procedure.

Workup

  1. customThis compound can be prepared
  2. temperaturetypically at reflux temperature
  3. waitfor about 1 h to about 5 h

Sources & evidence

ORD record
ord-64b9e4aebf85417d820911c308b9e13a
Source dataset
uspto-grants-2010_04
Patent number
US07700774B2

Reaction notes

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