反应详情

温度

80 °C

To a suspension of 149 mg of methyl (1S,2R)-1-({[8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]carbonyl}amino)-5-methylindane-2-carboxylate in 6 ml of dioxane was added 6 ml of 3 M hydrochloric acid, followed by stirring at 80° C. for 4 hours. After leaving to be cooled, the solvent was evaporated under reduced pressure, and then to the obtained residue were added a saturated aqueous sodium hydrogen carbonate solution, an aqueous citric acid solution, and chloroform to carry out a layer separation operation. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. To the obtained residue was added diisopropyl ether, and the insoluble material was collected by filtration and dried to obtain 126 mg of (1S,2R)-1-({[8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]carbonyl}amino)-5-methylindane-2-carboxylic acid.

1. customAfter leaving
2. temperatureto be cooled
3. customthe solvent was evaporated under reduced pressure
4. additionto the obtained residue were added a saturated aqueous sodium hydrogen carbonate solution
5. customa layer separation operation
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. customthe solvent was evaporated under reduced pressure
8. additionTo the obtained residue was added diisopropyl ether
9. filtrationthe insoluble material was collected by filtration
10. customdried