反应详情

温度

0 °C

A 100 mL round bottom flask equipped with a magnetic stir bar was charged with a solution of 1.002 g (2.52 mmol) of the product of Step C dissolved in 41 mL of tetrahydrofuran followed by the addition of 9 mL of water. The reaction mixture was stirred and cooled to 0° C. with an external ice-water bath and a fine suspension was observed. Lithium hydroxide (0.120 g, 5.02 mmol) was added followed by 1.71 mL (15.1 mmol) of 30% aqueous hydrogen peroxide. The reaction mixture was stirred for 1 h at room temperature during which time it developed a yellow color. The reaction mixture was then quenched by addition of excess saturated aqueous sodium sulfite and the tetrahydrofuran was removed in vacuo. The residue was extracted three times with methylene chloride to remove the oxazolidinone, then the aqueous layer was adjusted to pH=1-2 with 1 N hydrochloric acid. The aqueous layer was then extracted three times with ethyl acetate. The combined organic layers were dried (Na2SO4), filtered and evaporated in vacuo. The residual amorphous yellow solid (0.412 g) was used directly in the next step without further purification.

1. customA 100 mL round bottom flask equipped with a magnetic stir bar
2. stirringThe reaction mixture was stirred for 1 h at room temperature during which time it
3. customThe reaction mixture was then quenched by addition of excess saturated aqueous sodium sulfite
4. customthe tetrahydrofuran was removed in vacuo
5. extractionThe residue was extracted three times with methylene chloride
6. customto remove the oxazolidinone
7. extractionThe aqueous layer was then extracted three times with ethyl acetate
8. dry with materialThe combined organic layers were dried (Na2SO4)
9. filtrationfiltered
10. customevaporated in vacuo
11. customThe residual amorphous yellow solid (0.412 g) was used directly in the next step without further purification