反应详情

7-Methoxynaphtho[2,1-d]thiazole-2-carbonitrile (88 mg, 0.366 mmol) was suspended in 3 g of pyridine hydrochloride salt and sealed in a 5-mL microwave vial containing a stir bar. The mixture was irradiated at 220° C. for 25 minutes (min), then taken up in 1 N HCl and extracted three times with a mixture of DCM and EtOAc. The concentrated residue was purified by silica gel chromatography. 1H NMR (CD2Cl2) d 8.10 (d, 1H); 8.03 (d, 1H); 7.88 (d, 1H); 7.39 (d, 1H); 7.31 (dd, 1H);

1. customsealed in a 5-mL microwave vial
2. additioncontaining a stir bar
3. customThe mixture was irradiated at 220° C. for 25 minutes (min)
4. extractionextracted three times
5. additionwith a mixture of DCM and EtOAc
6. customThe concentrated residue was purified by silica gel chromatography