4-Methyloxybenzyl chloride → HCID 59263448, compound

HRID 645232Notes

Reaction equation

HRID 645232 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]2([CH2:13][O:12][C:11]3[CH:14]=[C:15]4[C:19](=[CH:20][C:10]2=3)[CH2:18][CH2:17][O:16]4)[C:2]1=[O:21].CC1(C)[CH2:27][O:26][C:25]2=[CH:28][C:29]3OC[C:32]4([C:42]=3[CH:43]=[C:24]12)C1C(=CC=CC=1)NC4=O.ClCC1C=CC(OC)=CC=1.BrCC1OC(C(F)(F)F)=CC=1>>[CH3:27][O:26][C:25]1[CH:28]=[CH:29][C:42]([CH2:32][N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]3([CH2:13][O:12][C:11]4[CH:14]=[C:15]5[C:19](=[CH:20][C:10]3=4)[CH2:18][CH2:17][O:16]5)[C:2]2=[O:21])=[CH:43][CH:24]=1

Participants

5

Reactant 4

HCID 699934-Methyloxybenzyl chlorideHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-oneHCID 592634705,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1H)-one

Product 1

HCID 59263448HCID 59263448, compound

Procedure

Following the procedure described in EXAMPLE 10.21, and making non-critical variations using 5,6-dihydrospiro[benzo[1,2-b:5,4-b′]difuran-3,3′-indol]-2′(1′H)-one to replace 5,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b′]difuran-3,3′-indol]-2′(1′H)-one, and 1-(chloromethyl)-4-methoxybenzene to replace 2-(bromomethyl)-5-(trifluoromethyl)furan, the title compound was obtained (56%) as a white solid: mp 120-121° C.; MS (ES+) m/z 400.2 (M+1).

Sources & evidence

ORD record
ord-ff3a0c583d2448a394352a8f0d7fe57c
Source dataset
uspto-grants-2010_04
Patent number
US07700641B2

Reaction notes

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