4-Methyloxybenzyl chloride → HCID 59263448, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Methyloxybenzyl chloride	HCID 69993	—
Reactant	2-(Bromomethyl)-5-(trifluoromethyl)furan	HCID 2794605	—
Reactant	5,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one	HCID 59263354	—
Reactant	5,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1H)-one	HCID 59263470	—
Product	HCID 59263448	HCID 59263448	—

Reaction Steps

Following the procedure described in EXAMPLE 10.21, and making non-critical variations using 5,6-dihydrospiro[benzo[1,2-b:5,4-b′]difuran-3,3′-indol]-2′(1′H)-one to replace 5,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b′]difuran-3,3′-indol]-2′(1′H)-one, and 1-(chloromethyl)-4-methoxybenzene to replace 2-(bromomethyl)-5-(trifluoromethyl)furan, the title compound was obtained (56%) as a white solid: mp 120-121° C.; MS (ES+) m/z 400.2 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07700641B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-ff3a0c583d2448a394352a8f0d7fe57c
Source note	uspto-grants-2010_04