HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(3,3-difluoropyrrolidin-1-YL)piperidine-1-carboxylate | HCID 53419023 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride | HCID 68711024 | — |
Reaction Steps
4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (1.77 mmol) is treated with 4N HCl in 1,4-dioxane (6 mL) and stirred at room temperature for 1 h. The reaction mixture is concentrated in vacuo and the resulting residue is used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07704996B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-a13adcd5765b4148a72afbf3d1f3fbc3 |
| Source note | uspto-grants-2010_04 |