Hydrochloric Acid → 4-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

HRID 645475Notes

Reaction equation

HRID 645475 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[F:20][C:16]1([F:19])[CH2:17][CH2:18][N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53419023Tert-butyl 4-(3,3-difluoropyrrolidin-1-YL)piperidine-1-carboxylate

Product 1

HCID 687110244-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (1.77 mmol) is treated with 4N HCl in 1,4-dioxane (6 mL) and stirred at room temperature for 1 h. The reaction mixture is concentrated in vacuo and the resulting residue is used for the next step without further purification.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe resulting residue is used for the next step without further purification

Sources & evidence

ORD record
ord-a13adcd5765b4148a72afbf3d1f3fbc3
Source dataset
uspto-grants-2010_04
Patent number
US07704996B2

Reaction notes

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