反应详情

温度

0 °C

To a solution of LAH (10 mmol) in THF (50 mL) is added 3-hydroxy-2-phenyl-1-pyrrolidin-1-yl propan-1-one (5 mmol) at 0° C. The reaction mixture is stirred at 0° C. for 1.5 h. After cooled down to 0° C., the reaction is quenched by the addition of Na2SO4-10H2O. The resulting mixture is filtered through celite, and the filtrate is concentrated in vacuo to give 2-phenyl-3-pyrrolidin-1-yl propan-1-ol, which is directly used for the next reaction without further purification.

1. temperatureAfter cooled down to 0° C.
2. customthe reaction is quenched by the addition of Na2SO4-10H2O
3. filtrationThe resulting mixture is filtered through celite
4. concentrationthe filtrate is concentrated in vacuo