HCID 68708639, compound → tert-Butyl [(4-phenylpiperidin-4-yl)methyl]carbamate

HRID 645485Notes

Reaction equation

HRID 645485 reaction equation
ClC(OC([N:7]1[CH2:12][CH2:11][C:10]([CH2:19][NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)=O)C>CO>[C:24]([O:23][C:21](=[O:22])[NH:20][CH2:19][C:10]1([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:11][CH2:12][NH:7][CH2:8][CH2:9]1)([CH3:27])([CH3:25])[CH3:26]

Participants

3

Reactant 1

HCID 68708639HCID 68708639, compound

Product 1

HCID 49760176tert-Butyl [(4-phenylpiperidin-4-yl)methyl]carbamate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 4-(tert-butoxycarbonylaminomethyl)-4-phenylpiperidine-1-carboxylic acid 1-chloroethyl ester in MeOH is stirred at 60° C. for 5 h, then the reaction mixture is concentrated in vacuo to give (4-phenylpiperidin-4-ylmethyl) carbamic acid tert-butyl ester, which is directly used for the next reaction without further purification.

Workup

  1. concentrationthe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-e4ad7842bfac4539befd6deb0806c9ab
Source dataset
uspto-grants-2010_04
Patent number
US07704996B2

Reaction notes

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