反应详情

To a stirred suspension of LAH (6.1 mmol) in THF (25 mL) is added dropwise a solution of 2-amino-1-morpholin-4-yl-2-phenylethanone (670 mmol) in THF (5 mL) at 0° C. The reaction mixture is refluxed for 2 hr, and then the reaction is quenched by the addition of Na2SO4-10H2O at 0° C. After stirring at room temperature for 0.5 h, the resulting mixture is filtered through celite, and the filtrate is concentrated in vacuo to give the title compound, which is directly used for the next reaction without further purification.

1. temperatureThe reaction mixture is refluxed for 2 hr
2. customthe reaction is quenched by the addition of Na2SO4-10H2O at 0° C
3. filtrationthe resulting mixture is filtered through celite
4. concentrationthe filtrate is concentrated in vacuo