HCID 16070101, compound → HCID 16725685, compound

HRID 645527Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=2[F:19])=[S:9])=[CH:6][N:5]=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][N:24]([S:27]([CH3:30])(=[O:29])=[O:28])[CH2:23][CH2:22]2)[N:3]=1.NC1C(C(C2C(OC)=CC=C(F)C=2F)=S)=CN=C(NC2CCC(S(C[CH2:61][CH2:62][N:63]3[CH2:68][CH2:67][O:66][CH2:65][CH2:64]3)(=O)=O)CC2)N=1.NC1C(C(C2C(OC)=CC=C(F)C=2F)=O)=CN=C(NC2CCC(S(CCCN3CCOCC3)(=O)=O)CC2)N=1>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[C:12]([F:18])[C:11]=2[F:19])=[S:9])=[CH:6][N:5]=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][N:24]([S:27]([CH2:30][CH2:61][CH2:62][N:63]3[CH2:68][CH2:67][O:66][CH2:65][CH2:64]3)(=[O:28])=[O:29])[CH2:23][CH2:22]2)[N:3]=1

Participants

Reactant 3

HCID 16070101HCID 16070101, compound

HCID 58880220HCID 58880220, compound

HCID 68676243HCID 68676243, compound

Product 1

HCID 16725685HCID 16725685, compound

Procedure

By a similar procedure to the preparation of the compound of Example 1, {4-Amino-2-[4-(3-morpholin-4-yl-propane-1-sulfonyl)-cyclohexylamino]-pyrimidin-5-yl}(2,3-difluoro-6-methoxy-phenyl)-methanethione was made from {4-Amino-2-[4-(3-morpholin-4-yl-propane-1-sulfonyl)-cyclohexylamino]-pyrimidin-5-yl}(2,3-difluoro-6-methoxy-phenyl)-methanone (prepared in accordance with US 2004/0162303 A1, 60 mg). LC/MS (m+H)+: 570.

Sources & evidence

ORD record: ord-9dda29d3da5b42bfb87c0fb8e5557618
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705009B2

Reaction notes

Loading…