1-Methyl-3-pyrrolidinol → 2-((1-Methylpyrrolidin-3-yl)oxy)nicotinonitrile

HRID 645547Notes

Reaction equation

HRID 645547 reaction equation
F[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:10][N:11]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12]1>>[CH3:10][N:11]1[CH2:15][CH2:14][CH:13]([O:16][C:2]2[N:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH2:12]1

Participants

3

Reactant 2

HCID 930741-Methyl-3-pyrrolidinolHCID 27832543-Cyano-2-fluoropyridine

Product 1

HCID 685851062-((1-Methylpyrrolidin-3-yl)oxy)nicotinonitrile

Procedure

2-Fluoro-nicotinonitrile was reacted with 1-methyl-pyrrolidin-3-ol according to the method of Example 85A to provide the title compound. MS (DCI/NH3) m/z 204 (M+1)+.

Sources & evidence

ORD record
ord-7bbc87c78a554a1c89b8120bf5cdbc27
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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