Formaldehyde → 1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one

HRID 645597Notes

Reaction equation

HRID 645597 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8](=[O:15])[CH2:7]2)[CH2:3][CH2:2]1.[CH2:16]=O>C(O)=O>[CH3:16][N:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8](=[O:15])[CH2:7]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 18467061spiro[indene-1,4'-piperidin]-3(2H)-one

Product 1

HCID 537128261'-methylspiro[indene-1,4'-piperidin]-3(2H)-one

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
120 °C

Procedure

To the product of Example 138A were added formic acid (88% sol, 0.64 g) and formaldehyde (36% sol, 0.45 g) and stirred at 120° C. overnight. The crude product was used in the next step.

Sources & evidence

ORD record
ord-baed56cc00774beab010d831cddc7c94
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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