HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 645597Generated: October 31, 2026
Formaldehyde → 1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one
https://huagongshe.com/reaction/645597
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | spiro[indene-1,4'-piperidin]-3(2H)-one | HCID 18467061 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 1'-methylspiro[indene-1,4'-piperidin]-3(2H)-one | HCID 53712826 | — |
Reaction Steps
To the product of Example 138A were added formic acid (88% sol, 0.64 g) and formaldehyde (36% sol, 0.45 g) and stirred at 120° C. overnight. The crude product was used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07704997B1 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-baed56cc00774beab010d831cddc7c94 |
|---|
| Source note | uspto-grants-2010_04 |
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