2-Chloronicotinonitrile → HCID 68583656, compound

HRID 645613Notes

Reaction equation

HRID 645613 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[F:10][C:11]([F:23])([F:22])[O:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[F:10][C:11]([F:22])([F:23])[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:2]2[N:3]=[CH:4][CH:5]=[CH:6][C:7]=2[C:8]#[N:9])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 27343864-(Trifluoromethoxy)phenylboronic acid

Product 1

HCID 68583656HCID 68583656, compoundYield 70%

Procedure

Prepared in 70% yield from 2-chloro-3-cyanopyridine and 4-trifluoromethoxyphenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 265.0 (M+H)+; 1H NMR (CDCl3) δ 7.37-7.44 (m, 3H), 7.98-8.03 (m, 2H), 8.10 (dd, J=8.0, 1.9 Hz, 1H), 8.89 (dd, J=4.7, 1.7 Hz, 1H).

Sources & evidence

ORD record
ord-98108807571f43d2aeaf69e9d32824c6
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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