Pyrrolidine → HCID 68583244, compound

HRID 645636Notes

Reaction equation

HRID 645636 reaction equation
Cl[C:2]1[N:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[C:4]#[N:5].[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>>[F:10][C:7]1[CH:8]=[N:9][C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 231108512-Chloro-5-fluoropyridine-3-carbonitrile

Product 1

HCID 68583244HCID 68583244, compoundYield 90%

Procedure

Prepared in 90% yield from the product of Example 169A and pyrrolidine according to the procedure described for Example 178A. MS (ESI+) m/z 192.0 (M+H)+; 1H NMR (DMSO-d6) δ 1.90-1.96 (m, 4H), 3.61-3.65 (m, 4H), 8.05 (dd, J=8.5, 3.0 Hz, 1H), 8.38 (d, J=3.0 Hz, 1H).

Sources & evidence

ORD record
ord-b3507c04202e4d5dbfb25e877612b1ee
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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