2-(4-Chlorophenyl)pyrrolidine → HCID 68582409, compound

HRID 645653Notes

Reaction equation

HRID 645653 reaction equation
Cl[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:8]=2[Cl:14])[N:5]=[N:4][N:3]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]2[CH2:26][CH2:25][CH2:24][NH:23]2)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([CH:22]2[CH2:26][CH2:25][CH2:24][N:23]2[C:2]2[N:6]([C:7]3[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:8]=3[Cl:14])[N:5]=[N:4][N:3]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 5923912-(4-Chlorophenyl)pyrrolidineHCID 59689467HCID 59689467, compound

Product 1

HCID 68582409HCID 68582409, compoundYield 10.1%

Procedure

The compound from Example 75B (0.1 g) was reacted with 2-(4-Chloro-phenyl)-pyrrolidine (0.1 g) according to the method of Example 75C to provide 0.016 g of the title compound as a white solid. MS (ESI/NH3) m/z 395 (M+H)+; 1H NMR (δ, DMSO-d6) 1.78-1.9 (m, 4H), 3.3-3.6 (m, 2H), 4.8-5.0 (m, 1H) 6.8-6.9 (m, 1H), 7.05-7.19 (m, 4H), 7.60-7.65 (t, 1H), 7.79-7.85 (d, 1H), 7.99-8.1 (d, 1H).

Sources & evidence

ORD record
ord-fa80057b5f09408a8bee65fbaed0524b
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

Loading…