Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 53486828 | — |
| Reactant | HCID 178434350 | HCID 178434350 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 178427345 | HCID 178427345 | 98.1% |
Reaction Steps
A mixture of 2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 0.585 mmol), 6-amino-3-methylindazole (94 mg, 0.64 mmol) and triethylamine (TEA) (0.200 mL, 1.44 mmol) in n-butyl alcohol (n-BuOH) (5 mL) was heated at 110° C. overnight. After cooling down, H2O and EtOAc were added. The organic phase was separated, washed with 1N HCl, followed by 5% NaHCO3, before being dried over Na2SO4 and concentrated in vacuo to give 2-chloro-N-(3-methyl-1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (260 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07705004B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-3a2218b1a0474e85bd600032a0c2b502 |
|---|
| Source note | uspto-grants-2010_04 |
|---|
