反应详情

温度

110 °C

A mixture of 2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 0.585 mmol), 6-amino-3-methylindazole (94 mg, 0.64 mmol) and triethylamine (TEA) (0.200 mL, 1.44 mmol) in n-butyl alcohol (n-BuOH) (5 mL) was heated at 110° C. overnight. After cooling down, H2O and EtOAc were added. The organic phase was separated, washed with 1N HCl, followed by 5% NaHCO3, before being dried over Na2SO4 and concentrated in vacuo to give 2-chloro-N-(3-methyl-1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (260 mg).

1. temperatureAfter cooling down
2. customThe organic phase was separated
3. washwashed with 1N HCl
4. dry with materialbefore being dried over Na2SO4
5. concentrationconcentrated in vacuo