反应详情

A mixture of 7.0 g (0.0264 mol) of product of Example 3, 30 ml of 10% sodium hydroxide and 10 ml of methanol was held at reflux for 18 hours, cooled and extracted with ether. The aqueous layer was made acidic and the precipitate was collected and dissolved in ether. The ether solution was dried and mixture was concentrated. The residual solid was recrystallized from hexane-ether to give 5.5 g (83%) of solid, mp 194°-197.5° C.

1. temperatureat reflux for 18 hours
2. temperaturecooled
3. extractionextracted with ether
4. customthe precipitate was collected
5. dissolutiondissolved in ether
6. dry with materialThe ether solution was dried
7. concentrationmixture was concentrated
8. customThe residual solid was recrystallized from hexane-ether