Piperidine → HCID 10248610, compound

HRID 645837Notes

Reaction equation

HRID 645837 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:7]1([N:11]2[CH2:17][CH2:16][C:15]3[CH:18]=[CH:19][C:20]([O:22][CH2:23][CH2:24][CH2:25][C:26](N4C=CN=C4)=[O:27])=[CH:21][C:14]=3[CH2:13][CH2:12]2)[CH2:10][CH2:9][CH2:8]1>ClCCl>[CH:7]1([N:11]2[CH2:17][CH2:16][C:15]3[CH:18]=[CH:19][C:20]([O:22][CH2:23][CH2:24][CH2:25][C:26](=[O:27])[N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:21][C:14]=3[CH2:13][CH2:12]2)[CH2:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 57440293HCID 57440293, compound

Product 1

HCID 10248610HCID 10248610, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Piperidine (0.1 ml, 1.1 mmol) was added to a stirred solution of 3-cyclobutyl-7-{[4-(1H-imidazol-1-yl)-4-oxobutyl]oxy}-2,3,4,5-tetrahydro-1H-3-benzazepine (E167, Step 1) (150 mg, 0.42 mmol) in dichloromethane (5 ml). After stirring at room temperature for 5 days the reaction mixture was concentrated in vacuo and the resulting residue was purified by column chromatography eluting with a mixture of 0.880 ammonia:ethanol:dichloromethane (1:9:90) to afford the title compound (E167); MS (ES+) m/e 371 [M+H]+.

Workup

  1. concentrationwas concentrated in vacuo
  2. customthe resulting residue was purified by column chromatography
  3. washeluting with a mixture of 0.880 ammonia:ethanol:dichloromethane (1:9:90)

Sources & evidence

ORD record
ord-64abe38b61d5479da9b28a72786910b4
Source dataset
uspto-grants-2010_04
Patent number
US07704994B2

Reaction notes

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