N-bromobutanimide → HCID 59264639, compound

HRID 645926Notes

Reaction equation

HRID 645926 reaction equation
C1C(=O)N([Br:8])C(=O)C1.[CH2:9]([O:11][C:12]([C:14]1[C:18]([CH3:19])=[C:17]([C:20]2[Se:21][CH:22]=[CH:23][CH:24]=2)[N:16]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=2[Cl:32])[N:15]=1)=[O:13])[CH3:10]>C(#N)C>[CH2:9]([O:11][C:12]([C:14]1[C:18]([CH3:19])=[C:17]([C:20]2[Se:21][C:22]([Br:8])=[CH:23][CH:24]=2)[N:16]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=2[Cl:32])[N:15]=1)=[O:13])[CH3:10]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 59264641HCID 59264641, compound

Product 1

HCID 59264639HCID 59264639, compoundYield 92.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

NBS (1.6 g, 9.34 mmol) was added in several small portions to a magnetically stirred solution of 1-(2,4-dichloro-phenyl)-4-methyl-5-selenophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester (2.0 g, 4.67 mmol) in acetonitrile at 0° C. The resulting mixture was stirred at room temperature for 48 h. The precipitate was filtered out, washed with saturated aqueous sodium sulfite and cold water, and then dried under vacuum to give the desired compound (2.2 g, 92%) as a white solid.

Workup

  1. filtrationThe precipitate was filtered out
  2. washwashed with saturated aqueous sodium sulfite and cold water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-977ec1d5e7574984a72f5a0be75b6758
Source dataset
uspto-grants-2010_04
Patent number
US07705024B2

Reaction notes

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