Hydrochloric Acid → HCID 59264648, compound

Participants

Reaction Steps

A solution of potassium hydroxide (442 mg, 7.88 mmol) in methanol (7 mL) was added to a magnetically stirred solution of 5-(5-Bromo-selenophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (2.0 g, 3.94 mmol) in methanol (15 mL). The mixture was heated under reflux for 3 h. The reaction mixture was cooled, poured into water, and acidified with 10% hydrochloric acid. The precipitate was filtered out, washed with water, and dried under vacuum to yield the corresponding acid (1.8 g, 95%) as a white solid.

Provenance & Evidence