Hydrochloric Acid → HCID 59264648, compound

HRID 645927Notes

Reaction equation

HRID 645927 reaction equation
[OH-].[K+].C([O:5][C:6]([C:8]1[C:12]([CH3:13])=[C:11]([C:14]2[Se:15][C:16]([Br:19])=[CH:17][CH:18]=2)[N:10]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=2[Cl:27])[N:9]=1)=[O:7])C.O.Cl>CO>[Br:19][C:16]1[Se:15][C:14]([C:11]2[N:10]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=3[Cl:27])[N:9]=[C:8]([C:6]([OH:7])=[O:5])[C:12]=2[CH3:13])=[CH:18][CH:17]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 59264639HCID 59264639, compound

Product 1

HCID 59264648HCID 59264648, compoundYield 95.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of potassium hydroxide (442 mg, 7.88 mmol) in methanol (7 mL) was added to a magnetically stirred solution of 5-(5-Bromo-selenophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (2.0 g, 3.94 mmol) in methanol (15 mL). The mixture was heated under reflux for 3 h. The reaction mixture was cooled, poured into water, and acidified with 10% hydrochloric acid. The precipitate was filtered out, washed with water, and dried under vacuum to yield the corresponding acid (1.8 g, 95%) as a white solid.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 3 h
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe precipitate was filtered out
  5. washwashed with water
  6. customdried under vacuum

Sources & evidence

ORD record
ord-43894972f59741d6b6a2e96f5c300f8e
Source dataset
uspto-grants-2010_04
Patent number
US07705024B2

Reaction notes

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