HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646054Generated: October 25, 2026
Acetic Anhydride → N-[1,1-dimethyl-2-(6-methyl-1H-indol-3-yl)-ethyl]-acetamide
https://huagongshe.com/reaction/646054
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-methyl-1-(6-methyl-1H-indol-3-yl)propan-2-amine | HCID 68579816 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[1,1-dimethyl-2-(6-methyl-1H-indol-3-yl)-ethyl]-acetamide | HCID 68580747 | — |
Reaction Steps
A solution of 1,1-dimethyl-2-(6-methyl-1H-indol-3-yl)-ethylamine (2 mmole, prepared according to Lit. 2) and acetic anhydride (2.2 mmole) in dichloromethane (3 ml) was treated with triethylamine (6 mmole) and the mixture was stirred at 22° C. for 18 h. The mixture was washed with aqueous hydrochloric acid (1N), the organic layer was dried and evaporated to give N-[1,1-dimethyl-2-(6-methyl-1H-indol-3-yl)-ethyl]-acetamide as a brownish solid. MS: 243.2 ([M−H]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07705034B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-876d7c68f52a437eba79f8fc38848296 |
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| Source note | uspto-grants-2010_04 |
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