(3,5-Dimethyl-benzo[b]thiophen-2-yl)-phenyl-methanol → 2-[(3,5-Dimethyl-benzo[b]thiophen-2-yl)-phenyl-methyl]-3-hydroxy-4-methyl-4-phenyl-cyclobut-2-enone

HRID 646085Notes

Reaction equation

HRID 646085 reaction equation
[CH3:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5](=[O:6])[CH2:4][C:3]1=[O:7].[CH3:14][C:15]1[C:16]2[CH:31]=[C:30]([CH3:32])[CH:29]=[CH:28][C:17]=2[S:18][C:19]=1[CH:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)O>>[CH3:14][C:15]1[C:16]2[CH:31]=[C:30]([CH3:32])[CH:29]=[CH:28][C:17]=2[S:18][C:19]=1[CH:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:4]1[C:3](=[O:7])[C:2]([CH3:1])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]=1[OH:6]

Participants

3

Reactant 2

HCID 68579524(3,5-Dimethyl-benzo[b]thiophen-2-yl)-phenyl-methanolHCID 685810272-Methyl-2-phenyl-cyclobutane-1,3-dione

Product 1

HCID 592649102-[(3,5-Dimethyl-benzo[b]thiophen-2-yl)-phenyl-methyl]-3-hydroxy-4-methyl-4-phenyl-cyclobut-2-enone

Procedure

23.2 Using general procedure D, 2-methyl-2-phenyl-cyclobutane-1,3-dione (Lit. 1) was reacted with (3,5-dimethyl-benzo[b]thiophen-2-yl)-phenyl-methanol to give the title compound as a colorless solid. MS: 423.5 ([M−H]−).

Sources & evidence

ORD record
ord-82de5354ed89456b976383ca71cb3022
Source dataset
uspto-grants-2010_04
Patent number
US07705034B2

Reaction notes

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