1-Bromo-4-(propan-2-yloxy)benzene → 1-(4-Isopropoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-indole-2-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[O:5])C.[F:16][C:17]([F:28])([F:27])[C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1.Br[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH:37]([CH3:39])[CH3:38])=[CH:32][CH:31]=1>>[CH:37]([O:36][C:33]1[CH:34]=[CH:35][C:30]([N:7]2[C:8]3[C:13](=[CH:12][C:11]([C:21]4[CH:22]=[CH:23][C:18]([C:17]([F:28])([F:27])[F:16])=[CH:19][CH:20]=4)=[CH:10][CH:9]=3)[CH:14]=[C:6]2[C:4]([OH:3])=[O:5])=[CH:31][CH:32]=1)([CH3:39])[CH3:38]Participants
4
Procedure
The title compound was prepared in accordance with Example 1, using 5-bromoindole-2-carboxylic acid ethyl ester, 4-(trifluoromethyl)phenyl-boronic acid and 4-bromo-1-isopropoxybenzene.
Sources & evidence
- ORD record
- ord-f4ba2a25fe58449d9d0640345c677210
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07705023B2
Reaction notes
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