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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646102Generated: October 29, 2026

1-Bromo-4-(propan-2-yloxy)benzene → 1-(4-Isopropoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-indole-2-carboxylic acid

https://huagongshe.com/reaction/646102

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-(propan-2-yloxy)benzeneHCID 228088—
ReactantEthyl 5-Bromoindole-2-carboxylateHCID 259091—
Reactant4-(Trifluoromethyl)phenylboronic acidHCID 2734389—
Product1-(4-Isopropoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-indole-2-carboxylic acidHCID 68696549—

Reaction Steps

The title compound was prepared in accordance with Example 1, using 5-bromoindole-2-carboxylic acid ethyl ester, 4-(trifluoromethyl)phenyl-boronic acid and 4-bromo-1-isopropoxybenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07705023B2
Source datasetuspto-grants-2010_04
ORD IDord-f4ba2a25fe58449d9d0640345c677210
Source noteuspto-grants-2010_04