Ethyl 5-(4-(tert-butyl)phenyl)-1H-indole-2-carboxylate → 5-(4-tert-Butylphenyl)-1-(4-(2-methyl-1-(pyrrolidin-1-yl)propan-2-yl-oxy)phenyl)indole-2-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:17][CH:16]=1)=[CH:10][CH:9]=2)=[O:5])C.Br[C:26]1[CH:41]=[CH:40][C:29]([O:30][C:31]([CH3:39])([CH3:38])[CH2:32][N:33]2[CH2:37][CH2:36][CH2:35][CH2:34]2)=[CH:28][CH:27]=1>>[C:21]([C:18]1[CH:17]=[CH:16][C:15]([C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]([C:26]2[CH:27]=[CH:28][C:29]([O:30][C:31]([CH3:39])([CH3:38])[CH2:32][N:33]4[CH2:34][CH2:35][CH2:36][CH2:37]4)=[CH:40][CH:41]=2)[C:6]([C:4]([OH:3])=[O:5])=[CH:14]3)=[CH:20][CH:19]=1)([CH3:22])([CH3:24])[CH3:23]Participants
3
Procedure
The title compound was prepared in accordance with Example 1 using 5-(4-tert-butylphenyl)indole-2-carboxylic acid ethyl ester and 1-(2-(4-bromophenoxy)-2-methylpropyl)pyrrolidine.
Sources & evidence
- ORD record
- ord-ba33aac5bdd446289cb99d395ada2990
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07705023B2
Reaction notes
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