HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 45923264 | HCID 45923264 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine hydrochloride | HCID 68697500 | 95% |
| Product | HCID 68697501 | HCID 68697501 | — |
Reaction Steps
1-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine was prepared in accordance to the procedure described in Example 29(a) from 2-(4-bromophenoxy)-2-methylpropanoyl chloride and 1-methylpiperazine (5.3 mL, 17.5 mmol). This compound (2.37 g, 6.95 mmol) was dissolved in Et2O and HCl in dioxane (4M, 2.26 mL) was added dropwise with stirring. The precipitate was filtered off and dried to yield the sub-title compound (2.5 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705023B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-0b005888c89b4786a135e67675814dcd |
| Source note | uspto-grants-2010_04 |