HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646133Generated: October 28, 2026
Carbon Tetrachloride → 3-Chloro-5-(4-isopropoxyphenyl)-1-(6-isopropoxypyrid-3-yl)indole-2-carboxylic acid ethyl ester
https://huagongshe.com/reaction/646133
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 5-(4-Isopropoxyphenyl)-1-(6-isopropoxypyrid-3-yl)indole-2-carboxylic acid | HCID 68696830 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Chloro-5-(4-isopropoxyphenyl)-1-(6-isopropoxypyrid-3-yl)indole-2-carboxylic acid ethyl ester | HCID 68701129 | 92% |
Reaction Steps
N-Chlorosuccinimide (37 mg, 280 nmol) and 5-(4-isopropoxyphenyl)-1-(6-isopropoxypyrid-3-yl)indole-2-carboxylic acid ethyl ester (117 mg, 255 nmol; see Example 17) were mixed in CCl4 (2 mL) and stirred at 80° C. for 2 h. The mixture was diluted with EtOAc and washed with Na2S2O3 (aq., 10%) and NaHCO3 (aq., sat.). The combined extracts were washed with water, brine and dried over Na2SO4. Concentration gave the sub-title compound (116 mg, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07705023B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-ab4b4ae233bf4bf68eee178cee2d0d75 |
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| Source note | uspto-grants-2010_04 |
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