反应详情

温度

80 °C

N-Chlorosuccinimide (37 mg, 280 nmol) and 5-(4-isopropoxyphenyl)-1-(6-isopropoxypyrid-3-yl)indole-2-carboxylic acid ethyl ester (117 mg, 255 nmol; see Example 17) were mixed in CCl4 (2 mL) and stirred at 80° C. for 2 h. The mixture was diluted with EtOAc and washed with Na2S2O3 (aq., 10%) and NaHCO3 (aq., sat.). The combined extracts were washed with water, brine and dried over Na2SO4. Concentration gave the sub-title compound (116 mg, 92%).

1. washwashed with Na2S2O3 (aq., 10%) and NaHCO3 (aq., sat.)
2. washThe combined extracts were washed with water, brine
3. dry with materialdried over Na2SO4
4. concentrationConcentration