[6-(Propan-2-yloxy)pyridin-3-yl]boronic acid → 1-(6-Isopropoxypyrid-3-yl)-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][N:16]=1)=[CH:10][CH:9]=2)=[O:5])[CH3:2].[CH:25]([O:28][C:29]1[N:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1)([CH3:27])[CH3:26]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C:32]2[CH:33]=[N:34][C:29]([O:28][CH:25]([CH3:27])[CH3:26])=[CH:30][CH:31]=2)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][N:16]=1)=[CH:10][CH:9]=2)=[O:5])[CH3:2]Participants
3
Procedure
The sub-title compound was prepared in accordance with Example 8(c) from 5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester (see Example 8(b)) and 6-isopropoxypyridine-3-boronic acid (see step (b) above).
Sources & evidence
- ORD record
- ord-60d9a1ce081942799a164e815637e6a5
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07705023B2
Reaction notes
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