反应详情

To a solution of 1-bromo-4-(2-bromoethoxy)benzene (19.9 g, 100 mmol; see step (a) above) in THF (120 mL) was portion-wise added t-BuOK (14.0 g, 125 mmol) over 10 min at 0° C. After stirring at room temperature for 16 h, the mixture was diluted with water (400 mL) and the product was extracted with light petrol (4×100 mL). The combined organic extracts were washed with brine, dried (Na2SO4), concentrated and distilled under vacuum to yield the sub-title compound (11.5 g, 58%).

1. extractionthe product was extracted with light petrol (4×100 mL)
2. washThe combined organic extracts were washed with brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. distillationdistilled under vacuum