反应详情

To mixture of 1-bromo-4-vinyloxybenzene (11.5 g, 58 mmol), chloroiodomethane (41 g, 232 mmol) and dichloroethane (180 mL) was added diethylzinc (15% solution in hexanes-95.5 mL, 116 mmol) over 3 h at 0° C. After 30 min stirring, NH4Cl solution (200 mL, aq. sat.) and light petrol (300 mL) was added. The organic phase was separated and concentrated in vacuo (8 bar, 50° C.). The residue was redissolved in light petrol and the insoluble material was filtered off. The filtrate was concentrated to afford sub-title compound (11.7 g, 94%).

1. customThe organic phase was separated
2. concentrationconcentrated in vacuo (8 bar, 50° C.)
3. dissolutionThe residue was redissolved in light petrol
4. filtrationthe insoluble material was filtered off
5. concentrationThe filtrate was concentrated