(4-Cyclopropoxyphenyl)boronic acid → 3-Chloro-1-(4-cyclopropoxyphenyl)-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][C:11]([C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=1)=[CH:10][CH:9]=2)=[O:5])C.[CH:26]1([O:29][C:30]2[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=2)[CH2:28][CH2:27]1>>[Cl:15][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:23])[F:24])=[CH:18][N:17]=3)[CH:12]=2)[N:7]([C:33]2[CH:34]=[CH:35][C:30]([O:29][CH:26]3[CH2:28][CH2:27]3)=[CH:31][CH:32]=2)[C:6]=1[C:4]([OH:3])=[O:5]Participants
3
Procedure
The title compound was prepared in accordance with Example 8(c) from 3-chloro-5-(5-trifluoromethylpyrid-2-yl)-1H-indole-2-carboxylic acid ethyl ester (see Example 36(a)) and 4-cyclopropoxyphenylboronic acid (see Example 40(a)), followed by ester hydrolysis in accordance with Example 1(c).
Sources & evidence
- ORD record
- ord-9b785d09f13d426795b40fe512ddd912
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07705023B2
Reaction notes
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